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KMID : 0624620120450100560
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BMB Reports
2012 Volume.45 No. 10 p.560 ~ p.564
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Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress
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Han Ying-Hao
Kwon Tae-Ho
Kim Sun-Uk
Ha Hye-Lin
Lee Tae-Hoon
Kim Jin-Man
Jo Eun-Kyeong
Kim Bo-Yeon
Yoon Do-Young
Yu Dae-Yeul
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Abstract
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The role of peroxiredoxin (Prx) I as an erythrocyte antioxidant defense in red blood cells (RBCs) is controversial. Here we investigated the function of Prx I by using Prx I(-/-) and Prx I/II(-/-) mice. Prx I(-/-) mice exhibited a normal blood profile. However, Prx I/II(-/-) mice showed more significantly increased Heinz body formation as compared with Prx II(-/-) mice. The clearancerate of Heinz body-containing RBCs in Prx I(-/-) mice decreased significantly through the treatment of aniline hydrochloride (AH) compared with wild-type mice. Prx I deficiency decreased the phagocytic capacity of macrophage in clearing Heinz body-containing RBCs. Our data demonstrate that Prx I deficiency did not cause hemolytic anemia, but showed that further increased hemolytic anemia symptoms in Prx II(-/-) mice by attenuating phagocytic capacity ofmacrophage in oxidative stress damaged RBCs, suggesting a novel role of Prx I in phagocytosis of macrophage.
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KEYWORD
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Heinz body, Hemolytic anemia, Macrophage, Peroxiredoxin, Phagocytosis
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